Selain penjualan berdasarkan volume, Oricon juga melakukan survey untuk penjualan terbaik di 2012 berdasarkan seri manga. Survey ini dilakukan mulai 21 November 2011 hingga 18 November 2012.
Masih sama seperti penjualan berdasarkan volume, One Piece berhasil mempimpin dengan perbedaan yang sangat jauh dengan peringkat kedua. Berikut adalah 30 manga di Jepang dengan penjualan terbaik di tahun 2012. Hampir semua judul yang ada dalam daftar ini telah mendapatkan adaptasi anime.
| Rank | Title | Creator | Estimated Copies Sold |
|---|---|---|---|
| 1 | One Piece | Eiichiro Oda | 23.464.866 |
| 2 | Kuroko no Basket | Tadatoshi Fujimaki | 8.070.446 |
| 3 | Naruto | Masashi Kishimoto | 6.459.240 |
| 4 | Uchuu Kyoudai | Chuuya Koyama | 5.413.899 |
| 5 | Fairy Tail | Hiro Mashima | 4.128.665 |
| 6 | Kimi ni Todoke | Karuho Shiina | 4.039.715 |
| 7 | Silver Spoon | Hiromu Arakawa | 3.603.710 |
| 8 | Hunter x Hunter | Yoshihiro Togashi | 3.439.839 |
| 9 | Magi | Shinobu Ohtaka | 3.437.182 |
| 10 | Bakuman | Story: Tsugumi Ohba Art: Takeshi Obata | 3.211.191 |
| 11 | Toriko | Mitsutoshi Shimabukuro | 3.005.339 |
| 12 | Bleach | Tite Kubo | 2.974.750 |
| 13 | Gintama | Hideaki Sorachi | 2.850.072 |
| 14 | Sket Dance | Kenta Shinohara | 2.786.109 |
| 15 | Shingeki no Kyoujin | Hajime Isayama | 2.682.504 |
| 16 | Chihayafuru | Yuki Suetsugu | 2.481.385 |
| 17 | Detective Conan | Gosho Aoyama | 2.430.572 |
| 18 | Ao no Exorcist | Kazue Katou | 2.262.565 |
| 19 | Thermae Romae | Mari Yamazaki | 2.231.198 |
| 20 | Inu x Boku SS | Cocoa Fujiwara | 2.153.552 |
| 21 | Kuroshitsuji | Yana Toboso | 2.008.593 |
| 22 | Bokura ga Ita | Yuuki Obata | 1.901.204 |
| 23 | Nurarihyon no Mago | Hiroshi Shiibashi | 1.879.120 |
| 24 | Katekyo Hitman Reborn! | Akira Amano | 1.884.824 |
| 25 | Kyou, Koi o Hajimemasu | Kanan Mikami | 1.838.940 |
| 26 | Beelzebub | Ryuuhei Tamura | 1.714.931 |
| 27 | Ace of Diamond | Yuuji Terajima | 1.685.194 |
| 28 | Natsume Yuujinchou | Yuki Midorikawa | 1.625.233 |
| 29 | Suki Desu Suzuki-kun!! | Gou Ikeyamada | 1.607.178 |
| 30 | Giant Killing | Story: Masaya Tsunamoto Art: Tsujitomo | 1.607.121 |
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